Nanoscale robotic ‘hand’ made of DNA could be used to detect viruses

Nanoscale robotic ‘hand’ made of DNA could be used to detect viruses

The design of the nanoscale hand that has a central palm and 4 bendable fingers made from DNA

Lifeng Zhou et al. (2023)

A nanoscale robotic hand with 4 bendable fingers can grasp objects like gold nanoparticles or viruses.

Xing Wang on the College of Illinois and his colleagues constructed the nanohand utilizing a technique known as DNA origami, during which a protracted, single strand of DNA is “stapled” collectively by shorter DNA items that pair with particular sequences on the longer strand. This technique can be utilized to create advanced shapes, from maps of the Americas to spinning nanoturbines.

The 4 fingers of the nanohand are joined to a “palm” to kind a cross form when the hand is open. Every finger is simply 71 nanometres lengthy (a nanometre is a billionth of a metre) and has three joints, like a human finger.

The researchers did a sequence of experiments to indicate what the fingers might be used for. To exhibit the greedy potential, they added strips of complementary DNA to particles of gold between 50 and 100 nanometres throughout and the fingers may grasp them.

In one other check, they took the fingers and added additional bits of DNA that bind to the spike protein of the SARS-CoV-2 virus. The nanohands may then “seize” viruses and people who had been grabbed have been unable to contaminate cells rising in a tradition.

Wang and his colleagues additionally engineered nanohands to fluoresce once they certain to a selected virus, which may assist detect such infectious brokers. They’re now exploring whether or not the units might be used to get medication into cells, says Wang.

One benefit of the nanohands for such functions is that standard DNA is damaged down quickly by enzymes within the blood, however DNA origami buildings are extra secure. They can be made to last more through the use of ultraviolet gentle to create additional bonds between the strands or by coating them in sure polymers, says Wang.

“Now we have began animal checks, however with totally different DNA nanostructures, a while in the past,” he says.

“The design seems to be actually distinctive and will encourage others,” says Matthew Aquilina on the College of Edinburgh, UK.


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